Order Gastrointestinal Disease Discussion

Order Gastrointestinal Disease Discussion
Order Gastrointestinal Disease Discussion
QUESTIONS
Question 1
Please explain the role of the sympathetic nervous system in the
gastrointestinal tract.
Question 2
What is the difference between a submandibular salivary gland swelling
and swelling of a salivary lymph node?
Question 3
How does Barrett’s oesophagus develop?
Question 4
Is it recommended to treat asymptomatic endoscopically diagnosed
reflux oesophagitis with acid suppression and/or antireflux
measures?
Question 5
Is it recommended to give a young patient, diagnosed endoscopically to
have mild reflux oesophagitis, life-long proton pump inhibitors (PPIs) to
prevent the development of Barrett’s oesophagitis?
Question 6
Is it safe to give a patient with reflux oesophagitis who is on proton
pump inhibitors (PPIs) for treatment of acid suppression, aspirin in
antiplatelet doses (75–325 mg per day)?
Question 7
Does a combination of magnesium and aluminium hydroxide salts,
taken as antacid for reflux oesophagitis, have serious long-term adverse
effects? 33
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6 Gastrointestinal disease
34
Question 8
In the treatment of reflux oesophagitis with a proton pump inhibitor
(PPI), should the PPI be life long or given for 4–8 weeks, as mentioned by
the drug manufacturers?
Question 9
Would a patient who suffers with reflux oesophagitis as a result of a
hiatus hernia, and who is not responsive to proton pump inhibitors
(PPIs), benefit from a highly selective vagotomy?
Question 10
1. What are the causes of belching and what appropriate drug can be
used?
2. What are the effects of smoking on the gastrointestinal tract and what
is its role in peptic ulcer disease?
Question 11
Dear authors, why are gastric ulcers more common along the lesser
curve, near the pylorus of the stomach?
Question 12
What is the best time of day to administer omeprazole, and why?
Question 13
Is it safe to use the drugs omeprazole and ranitidine during pregnancy?
Question 14
Are non-steroidal anti-inflammatory drugs harmful to the stomach when
taken parenterally, for example by intravenous or intramuscular routes?
Question 15
Is it safe to give a patient with a past history of bleeding peptic ulcer
aspirin in an antiplatelet dose of 75–325 mg?
Question 16
Is sulpiride effective in the treatment of a peptic ulcer or gastrooesophageal reflux disease (GORD)?
Question 17
Is clopidogrel gentle on the stomach?
Question 18
Is there a drug interaction between non-steroidal anti-inflammatory
drugs (NSAIDs) and proton pump inhibitors (PPIs)?
Gastrointestinal disease 6
35
Question 19
Do antacids enhance mucosal resistance in the gastric mucosa? If so,
please indicate the mechanism.
Question 20
Is there a drug interaction between antacids and H2-receptor blockers?
Question 21
Does the combination of aluminium and magnesium hydroxide, given
as an antacid, decrease the absorption of omeprazole if these are
co-administered to help relieve heartburn quickly?
Question 22
Should proton pump inhibitors be used with caution in patients with
renal impairment?
Question 23
Has cisapride been withdrawn from the market because of the danger of
ventricular fibrillation?
Question 24
In peptic ulcer disease:
1. What are the indications for an upper gastrointestinal endoscopy?
2. As this is an invasive procedure, is an oesophagogastroduodenoscopy
(OGD) or barium meal X-ray preferable?
Question 25
Is telithromycin as, or more, effective than clarithromycin in the
treatment of Helicobacter pylori? If so, what is the recommended dosage
and how long should treatment be continued?
Order Gastrointestinal Disease Discussion
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