Order Vascular Biology Homework Assignment

Order Vascular Biology Homework Assignment
Order Vascular Biology Homework Assignment
1 All of the following statements regarding the American Heart Association (AHA) classification for early
atherosclerosis are true, except:
(A) The type I lesion is proteoglycan rich and prone
to develop atherosclerosis
(B) The type II lesion is characterized by foam cell
infiltration and may regress
(C) The type III lesion is characterized by pools of
intracellular lipid and collagen
(D) Early lesions are flat, asymptomatic, and do not
obstruct the lumen
2 All of the following statements regarding advanced
atherosclerosis are true, except:
(A) Vasa vasorum neovascularization is increased in
ruptured plaques
(B) Thin-cap fibroatheromas are characterized by
cap thickness <65 µm, macrophages, and large
lipid core
(C) Extravasation of red blood cells (RBCs) within
plaques increases lipid core expansion
(D) Plaque rupture is most frequently symptomatic,
leading to acute coronary events
3 All of the following statements regarding advanced
atherosclerosis are true, except:
(A) Coronary calcification is a predictor of future
coronary events
(B) Coronary calcification always reflects advanced
disease by histologic criteria
(C) Plaque erosion is more frequently seen in
smokers
(D) Chronic stable angina lesions are frequently
healed ruptured plaques
(E) Plaque rupture more frequently occurs at the
center of the fibrous cap
4 All of the following statements are true, except:
(A) Nonobstructive lesions are the most frequent
cause of acute myocardial infarction (MI)
(B) Obstructive lesions can evolve into complete
occlusion silently
(C) The individual risk for plaque progression to
complete occlusion is higher in nonobstructive
lesions
(D) Vulnerable plaques are located predominately in
the proximal segments of the coronary arteries
5 All of the following statements are true, except:
(A) Plaque rupture may occur simultaneously in
two different arteries
(B) Plaque healing after rupture is mediated by
smooth muscle cell (SMC) production of collagen III
(C) SMCs are responsible for weakening the fibrous
cap
Order Vascular Biology Homework Assignment
(D) T lymphocytes increase proteolytic activity and
decrease collagen synthesis
6 All of the following statements are true, except:
(A) Inflammation precipitates plaque rupture and
thrombosis
(B) Collagen is the most thrombogenic substrate
after plaque rupture
(C) Inflammation promotes neovascularization
(D) Macrophages are the main source of metalloproteinases in the plaque
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